The Notebooks of Leonardo Da Vinci

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Page 848 of 1565.
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Death in old men, when not from fever, is caused by the veins which
go from the spleen to the valve of the liver, and which thicken so
much in the walls that they become closed up and leave no passage
for the blood that nourishes it.

[6]The incessant current of the blood through the veins makes these
veins thicken and become callous, so that at last they close up and
prevent the passage of the blood.

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